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E-Ring 8-isoprostanes inhibit ACh release from parasympathetic nerves innervating guinea-pig trachea through agonism of prostanoid receptors of the EP(3)-subtype

1. In the present study, we examined the effect of E-ring 8-isoprostanes on cholinergic neurotransmission in guinea-pig trachea and identified the receptor(s) involved. As isoprostanes are isomeric with prostaglandins, PGE(2) and sulprostone (a selective EP(3)-receptor agonist) were examined in para...

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Detalhes bibliográficos
Main Authors: Clarke, Deborah L, Giembycz, Mark A, Patel, Hema J, Belvisi, Maria G
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574232/
https://ncbi.nlm.nih.gov/pubmed/14744812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705648
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