Role of PKC in the attenuation of the cGMP-mediated relaxation of skinned resistance artery smooth muscle seen in glyceryl-trinitrate-tolerant rabbit

1. We examined whether 10 days' in vivo treatment with glyceryl trinitrate (GTN) might reduce cGMP-induced relaxation in the smooth muscle of rabbit mesenteric resistance arteries and, if so, whether protein kinase C (PKC) plays a role in this downregulation. 2. The relaxation responses to GTN...

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Bibliographic Details
Main Authors: Nakano, Youichirou, Kusama, Nobuyoshi, Kajikuri, Junko, Suzuki, Yoshikatsu, Kanmura, Yuichi, Itoh, Takeo
Format: Artigo
Language:Inglês
Published: 2004
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574208/
https://ncbi.nlm.nih.gov/pubmed/14718264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705625
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