Effects of the neutral endopeptidase inhibitor thiorphan on cardiovascular and renal function in cirrhotic rats

1. Cirrhosis is associated with cardiovascular and renal dysfunction including sodium retention. Many vasoactive peptides such as atrial natriuretic peptide (ANP) and endothelin-1 (ET-1) are degraded by neutral endopeptidase 24.11 (NEP). We investigated the hemodynamic and renal effects of thiorphan...

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Bibliographic Details
Main Authors: Park, K S, Li, Y, Zhang, Y, Gerbes, A L, Liu, H, Swain, M G, Lee, S S
Format: Artigo
Language:Inglês
Published: 2003
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573821/
https://ncbi.nlm.nih.gov/pubmed/12746226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705219
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