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The anti-inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species
1. The mechanism of action by which methotrexate (MTX) exerts its anti-inflammatory and immunosuppressive effects remains unclear. The aim of this study is to investigate the hypothesis that MTX exerts these effects via the production of reactive oxygen species (ROS). 2. Addition of MTX (100 nM–10 μ...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1573681/ https://ncbi.nlm.nih.gov/pubmed/12569075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705054 |
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