Unproductive cleavage and the inactivation of protease-activated receptor-1 by trypsin in vascular endothelial cells

1. Using fura-2 fluorometry of [Ca(2+)](i) in response to thrombin, trypsin and protease-activated receptor activating peptides (PAR-APs), we determined whether trypsin cleaves protease-activated receptor 1 (PAR1) and activates it in the endothelial cells of the porcine aortic valves and human umbil...

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Bibliographic Details
Main Authors: Nakayama, Tetsuzo, Hirano, Katsuya, Shintani, Yoshinobu, Nishimura, Junji, Nakatsuka, Akio, Kuga, Hirotaka, Takahashi, Shosuke, Kanaide, Hideo
Format: Artigo
Language:Inglês
Published: 2003
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573634/
https://ncbi.nlm.nih.gov/pubmed/12522081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705008
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