Ebselen attenuates oxidative stress-induced apoptosis via the inhibition of the c-Jun N-terminal kinase and activator protein-1 signalling pathway in PC12 cells

1. Ebselen (2-phenyl-1,2-benzisoselenazol-3[2H]-one) is a selenoorganic compound exhibiting both glutathione peroxidase activity and antioxidant activity. Although it has been reported that ebselen is effective for oxidative stress-induced neuronal damage both in vivo and clinically, the precise mec...

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Main Authors: Yoshizumi, Masanori, Kogame, Toshiaki, Suzaki, Yuki, Fujita, Yoshiko, Kyaw, Moe, Kirima, Kazuyoshi, Ishizawa, Keisuke, Tsuchiya, Koichiro, Kagami, Shoji, Tamaki, Toshiaki
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573436/
https://ncbi.nlm.nih.gov/pubmed/12145102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704808
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