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Inhibitory effects of tramadol on nicotinic acetylcholine receptors in adrenal chromaffin cells and in Xenopus oocytes expressing α7 receptors

1. Tramadol has been used clinically as an analgesic; however, the mechanism of its analgesic effects is still unknown. 2. We used bovine adrenal chromaffin cells to investigate effects of tramadol on catecholamine secretion, nicotine-induced cytosolic Ca(2+) concentration ([Ca(2+)](i)) increases an...

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Hlavní autoři: Shiraishi, Munehiro, Minami, Kouichiro, Uezono, Yasuhito, Yanagihara, Nobuyuki, Shigematsu, Akio, Shibuya, Izumi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2002
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573343/
https://ncbi.nlm.nih.gov/pubmed/12010769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704703
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