Dexrazoxane pre-treatment protects skinned rat cardiac trabeculae against delayed doxorubicin-induced impairment of crossbridge kinetics

1. Dexrazoxane (DXR, ICRF-187) has been shown both in animal studies and clinical trials to provide a substantial cardioprotection when co-administered with anthracycline drugs like Doxorubicin (DOX). In a previous study, we showed that chronic DOX treatment in rats is associated with a clear impair...

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Detalhes bibliográficos
Main Authors: Beer, Evert L de, Bottone, Antonio E, Rijk, Maartje C van, Velden, Jolanda van der, Voest, Emile E
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573287/
https://ncbi.nlm.nih.gov/pubmed/11934811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704621
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