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Modulation of contraction by α(2A/D)-adrenoceptors in mouse aorta: evidence employing knockout technology

1. We have investigated noradrenaline-evoked contractions in endothelium-denuded aorta from wild-type and α(2A/D)-adrenoceptor knockout mice. The maximum contraction to noradrenaline was significantly larger (1.36±0.24 mN, n=5) in aorta from knockout than from wild-type animals (0.78±0.14 mN, n=12,...

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Detalhes bibliográficos
Main Authors: Vandeputte, Catherine, Docherty, James R
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573231/
https://ncbi.nlm.nih.gov/pubmed/11877328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704567
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