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Multiple pathways for fluoroquinolone secretion by human intestinal epithelial (Caco-2) cells

1. Human intestinal epithelial Caco-2 cells, T84 cells, and MDCKII cells transfected with human MDR1, were used to investigate the mechanistic basis of transintestinal fluoroquinolone secretion. 2. The fluoroquinolone grepafloxacin was secreted across Caco-2 monolayers by a saturable process (V(max)...

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Detalhes bibliográficos
Main Authors: Lowes, Simon, Simmons, Nicholas L
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573224/
https://ncbi.nlm.nih.gov/pubmed/11877335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704560
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