Impairment of myocardial contractility by anticancer anthracyclines: role of secondary alcohol metabolites and evidence of reduced toxicity by a novel disaccharide analogue

1. The anticancer anthracycline doxorubicin (DOX) causes cardiotoxicity. Enzymatic reduction of a side chain carbonyl group converts DOX to a secondary alcohol metabolite that has been implicated in cardiotoxicity. We therefore monitored negative inotropism, assessed as inhibition of post-rest contr...

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Detalhes bibliográficos
Main Authors: Minotti, Giorgio, Parlani, Massimo, Salvatorelli, Emanuela, Menna, Pierantonio, Cipollone, Amalia, Animati, Fabio, Maggi, Carlo A, Manzini, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573059/
https://ncbi.nlm.nih.gov/pubmed/11704647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704369
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