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Reciprocal regulation of cyclic GMP content by cyclic GMP-phosphodiesterase and guanylate cyclase in SHR with CsA-induced nephrotoxicity
1. The effect of the immunosuppressant drug, cyclosporin A (CsA), on the nitric oxide (NO)-cyclic GMP pathway was examined in spontaneous hypertensive rats (SHR). 2. CsA (50 mg kg(−1)) treatment for 14 days induced typical CsA nephrotoxicity, which was characterized by morphological changes in the g...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1573030/ https://ncbi.nlm.nih.gov/pubmed/11682447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704337 |
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