Synthesis and characterization of a quinolinonic compound activating ATP-sensitive K(+) channels in endocrine and smooth muscle tissues

1. Original quinolinone derivatives structurally related to diazoxide were synthesized and their effects on insulin secretion from rat pancreatic islets and the contractile activity of rat aortic rings determined. 2. A concentration-dependent decrease of insulin release was induced by 6-chloro-2-met...

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Detalhes bibliográficos
Main Authors: Becker, B, Antoine, M-H, Nguyen, Q-A, Rigo, B, Cosgrove, K E, Barnes, P D, Dunne, M J, Pirotte, B, Lebrun, P
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572960/
https://ncbi.nlm.nih.gov/pubmed/11564656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704266
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