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Influence of the 5-HT(2C) receptor antagonist SB242,084 on behaviour produced by the 5-HT(2) agonist Ro60-0175 and the indirect 5-HT agonist dexfenfluramine

1. Ro60-0175 has been described as a selective agonist at the 5-HT(2C) receptor, yet it has only 10- fold higher affinity at the 5-HT(2C) compared to the 5-HT(2A) subtype, and equivalent affinity for the 5-HT(2B) receptor. 2. The selective 5-HT(2C) receptor antagonist SB242,084 (0.5 mg kg(−1) i.p.),...

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Hlavní autoři: Higgins, G A, Ouagazzal, A M, Grottick, A J
Médium: Artigo
Jazyk:Inglês
Vydáno: 2001
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572804/
https://ncbi.nlm.nih.gov/pubmed/11399662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704082
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