HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme

The present study examined the inhibitory effects of N-Hydroxy-N′-(4-butyl-2-methylphenyl)-formamidine (HET0016) on the renal metabolism of arachidonic acid by cytochrome P450 (CYP) enzymes. HET0016 exhibited a high degree of selectivity in inhibiting the formation of 20-hydroxy-5,8,11,14-eicosatetr...

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Detalhes bibliográficos
Main Authors: Miyata, Noriyuki, Taniguchi, Kazuo, Seki, Takayuki, Ishimoto, Tsuyoshi, Sato-Watanabe, Mariko, Yasuda, Yoshiko, Doi, Mariko, Kametani, Shunichi, Tomishima, Yasumitsu, Ueki, Tomokazu, Sato, Masakazu, Kameo, Kazuya
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
Assuntos:
Special Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572803/
https://ncbi.nlm.nih.gov/pubmed/11375247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704101
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