Transfection of annexin 1 in monocytic cells produces a high degree of spontaneous and stimulated apoptosis associated with caspase-3 activation

1. Transfection of the pre-monomyelocytic U937 cell line with a plasmid coding for full-length annexin 1 (ANX1, 347 amino acid) leads to cell death by promoting apoptosis. In addition, over-expression of the N-terminal and the first domain of the protein (144 amino acids, clone ANX1-S), which does n...

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Hauptverfasser: Solito, Egle, de Coupade, Catherine, Canaider, Silvia, Goulding, Nicolas J, Perretti, Mauro
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2001
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Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572776/
https://ncbi.nlm.nih.gov/pubmed/11350857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704054
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