Role of p38 MAP kinase in LPS-induced airway inflammation in the rat

1. We investigated the effect of the p38 kinase inhibitor SB 203580 on airway inflammation induced by aerosolized lipopolysaccharide (LPS) in male Wistar rats. SB 203580 significantly inhibited (ED(50)=15.8 mg kg(−1)) plasma levels of TNF-α in rats challenged with LPS (1.5 mg kg(−1), i.p.). 2. Aeros...

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Bibliographic Details
Main Authors: Haddad, El-Bdaoui, Birrell, Mark, McCluskie, Kerryn, Ling, Andrea, Webber, Stephen E, Foster, Martyn L, Belvisi, Maria G
Format: Artigo
Language:Inglês
Published: 2001
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572739/
https://ncbi.nlm.nih.gov/pubmed/11309243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704022
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