Role of p38 MAP kinase in LPS-induced airway inflammation in the rat

1. We investigated the effect of the p38 kinase inhibitor SB 203580 on airway inflammation induced by aerosolized lipopolysaccharide (LPS) in male Wistar rats. SB 203580 significantly inhibited (ED(50)=15.8 mg kg(−1)) plasma levels of TNF-α in rats challenged with LPS (1.5 mg kg(−1), i.p.). 2. Aeros...

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Bibliographische Detailangaben
Hauptverfasser: Haddad, El-Bdaoui, Birrell, Mark, McCluskie, Kerryn, Ling, Andrea, Webber, Stephen E, Foster, Martyn L, Belvisi, Maria G
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2001
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Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572739/
https://ncbi.nlm.nih.gov/pubmed/11309243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704022
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