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Ligand internalization and recycling by human recombinant somatostatin type 4 (h sst(4)) receptors expressed in CHO-K1 cells

1. There is controversy as to whether somatostatin sst(4) receptors internalize. In this study, CHO-K1 cells expressing human sst(4) receptor (CHOsst(4) cells) cells internalized [(125)I]-[(11)Tyr]-SRIF in a time-dependent manner, reaching a steady state at 60 min (1.4±0.1×10(4) molecules internaliz...

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Detalles Bibliográficos
Main Authors: Smalley, K S M, Koenig, J A, Feniuk, W, Humphrey, P P A
Formato: Artigo
Idioma:Inglês
Publicado: 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572639/
https://ncbi.nlm.nih.gov/pubmed/11226141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703896
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