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Inhibition of endotoxin-induced vascular hyporeactivity by 4-amino-tetrahydrobiopterin
1. The 4-amino analogue of tetrahydrobiopterin (4-ABH(4)) is a potent pterin-site inhibitor of nitric oxide synthases (NOS). Although 4-ABH(4) does not exhibit selectivity between purified NOS isoforms, a pronounced selectivity of the drug towards inducible NOS (iNOS) is apparent in intact cells. Th...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2000
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1572510/ https://ncbi.nlm.nih.gov/pubmed/11139456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703752 |
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