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4-Aminopyridine affects rat arterial smooth muscle BK(Ca) currents by changing intracellular pH

1. The hypothesis whether or not 4-AP can affect vascular smooth muscle BK(Ca) currents was tested using the patch-clamp technique, pH- and calcium-fluorimetry, and freshly isolated rat arterial smooth muscle cells. 2. Application of 4-AP reversibly inhibited BK(Ca) currents at an intracellular calc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Petkova-Kirova, Polina, Gagov, Hristo, Krien, Ulrike, Duridanova, Dessislava, Noack, Thomas, Schubert, Rudolf
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2000
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572501/
https://ncbi.nlm.nih.gov/pubmed/11139442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703742
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