Effects of acidosis and NO on nicorandil-activated K(ATP) channels in guinea-pig ventricular myocytes

1. Nicorandil is a hybrid compound of K(+) channel opener and nitrate. We investigated a possible interaction of acidosis and nitric oxide (NO)-donors on the nicorandil-activated ATP-sensitive K(+) channel (K(ATP)) in guinea-pig ventricular myocytes using the patch-clamp technique. 2. In whole-cell...

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Hlavní autoři: Moncada, Gustavo A, Kishi, Yukio, Numano, Fujio, Hiraoka, Masayasu, Sawanobori, Tohru
Médium: Artigo
Jazyk:Inglês
Vydáno: 2000
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Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572434/
https://ncbi.nlm.nih.gov/pubmed/11082116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703678
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