In vivo transfer of antisense oligonucleotide against urinary kininase blunts deoxycorticosterone acetate-salt hypertension in rats

1. We have previously reported that the renal kallikrein-kinin system suppressed the development of deoxycorticosterone acetate (DOCA)-salt hypertension. Kinins were degraded in the kidney mainly by carboxypeptidase Y (CPY)-like kininase. Blockade of renal kinin degradation may reduce hypertension i...

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Bibliographische Detailangaben
Hauptverfasser: Hayashi, Izumi, Majima, Masataka, Fujita, Tomoe, Okumura, Toshiaki, Kumagai, Yuji, Tomita, Naruya, Morishita, Ryuichi, Higaki, Jitsuo, Ogiwara, Toshio
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2000
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Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572391/
https://ncbi.nlm.nih.gov/pubmed/11030733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703634
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