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Pharmacological evaluation of the role of cytochrome P450 in intracellular calcium signalling in rat pancreatic acinar cells

1. We have investigated whether the cytochrome P450 system is involved in Ca(2+) signalling in rat pancreatic acinar cells. Intracellular free [Ca(2+)] ([Ca(2+)](i)) was measured in collagenase-isolated cells using fura-2 microspectrofluorimetry and imaging. 2. The imidazole P450 inhibitor ketoconaz...

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Detalhes bibliográficos
Main Authors: Bruce, Jason I E, Elliott, Austin C
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572388/
https://ncbi.nlm.nih.gov/pubmed/11030726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703631
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