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Mechanisms underlying the chronic pravastatin treatment-induced improvement in the impaired endothelium-dependent aortic relaxation seen in streptozotocin-induced diabetic rats

1. We investigated the effects of chronic pravastatin treatment on the impaired endothelium-dependent relaxation seen in aortae from established streptozotocin (STZ)-induced diabetic rats. Starting at 6 weeks of diabetes, pravastatin (10 mg kg(−1)) was administered to STZ-induced diabetic rats for 4...

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Detalhes bibliográficos
Main Authors: Kobayashi, Tsuneo, Matsumoto, Takayuki, Kamata, Katsuo
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572325/
https://ncbi.nlm.nih.gov/pubmed/10991915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703572
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