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Prevention by dexrazoxane of down-regulation of ryanodine receptor gene expression in anthracycline cardiomyopathy in the rat

Anthracyclines can cause cumulative dose-related cardiotoxicity characterized by changes in Ca(2+) metabolism, including dysfunction of the sacroplasmic reticulum (SR) and decreased expression of Ca(2+)-handling proteins, such as the ryanodine receptor (RyR2). In this study, we examined the effect o...

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Detalles Bibliográficos
Main Authors: Burke, Briant E, Gambliel, Hervé, Olson, Richard D, Bauer, Frederic K, Cusack, Barry J
Formato: Artigo
Idioma:Inglês
Publicado: 2000
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572297/
https://ncbi.nlm.nih.gov/pubmed/10960060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703538
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