Sulphonylurea drugs reduce hypoxic damage in the isolated perfused rat kidney

1. Sulphonylurea drugs have been shown to protect against hypoxic damage in isolated proximal tubules of the kidney. In the present study we investigated whether these drugs can protect against hypoxic damage in a whole kidney preparation. 2. Tolbutamide (200 μM) and glibenclamide (10 μM) were appli...

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Autori principali: Engbersen, Richard, Moons, Miek M, Wouterse, Alfons C, Dijkman, Henry B, Kramers, Cees, Smits, Paul, Russel, Frans G M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2000
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Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572226/
https://ncbi.nlm.nih.gov/pubmed/10928974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703469
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