Characteristics of the Ca(2+)-dependent inhibition of cyclic AMP accumulation by histamine and thapsigargin in human U373 MG astrocytoma cells

1. Histamine, acting on H(1)-receptors, caused a Ca(2+)-dependent inhibition of forskolin- and isoprenaline-induced cyclic AMP accumulation in monolayers of human U373 MG cells (IC(50) 1.3±0.3 μM, maximum inhibition 66±3%). The inhibition was not reversed by the protein kinase inhibitor K-252A. 2. T...

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Главные авторы: Wong, M-P Mabel, Cooper, Dermot M F, Young, Kenneth W, Young, J Michael
Формат: Artigo
Язык:Inglês
Опубликовано: 2000
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Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572168/
https://ncbi.nlm.nih.gov/pubmed/10882386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703411
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