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Characteristics of the Ca(2+)-dependent inhibition of cyclic AMP accumulation by histamine and thapsigargin in human U373 MG astrocytoma cells
1. Histamine, acting on H(1)-receptors, caused a Ca(2+)-dependent inhibition of forskolin- and isoprenaline-induced cyclic AMP accumulation in monolayers of human U373 MG cells (IC(50) 1.3±0.3 μM, maximum inhibition 66±3%). The inhibition was not reversed by the protein kinase inhibitor K-252A. 2. T...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2000
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1572168/ https://ncbi.nlm.nih.gov/pubmed/10882386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703411 |
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