Substance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin-1 receptor in rats and mice

1. Pancreatic oedema occurs early in the development of acute pancreatitis, and the overall extent of fluid loss correlates with disease severity. The tachykinin substance P (SP) is released from sensory nerves, binds to the neurokinin-1 receptor (NK1-R) on endothelial cells and induces plasma extra...

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Detalhes bibliográficos
Main Authors: Grady, Eileen F, Yoshimi, Shandra K, Maa, John, Valeroso, Dahlia, Vartanian, Robert K, Rahim, Shamila, Kim, Edward H, Gerard, Craig, Gerard, Norma, Bunnett, Nigel W, Kirkwood, Kimberly S
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572103/
https://ncbi.nlm.nih.gov/pubmed/10821777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703343
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