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Loss of muscarinic antinociception by antisense inhibition of M(1) receptors

1. The effect on cholinergic analgesia of inactivation of the M(1) gene by an antisense oligodeoxyribonucleotide (aODN) was investigated in the mouse hot plate test. Mice received a single intracerebroventricular (i.c.v.) injection of anti-M(1) aODN (0.3, 1.0 or 2.0 nmol per injection), degenerate O...

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Bibliografische gegevens
Hoofdauteurs: Ghelardini, Carla, Galeotti, Nicoletta, Bartolini, Alessandro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2000
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572021/
https://ncbi.nlm.nih.gov/pubmed/10780968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703268
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