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Loss of muscarinic antinociception by antisense inhibition of M(1) receptors

1. The effect on cholinergic analgesia of inactivation of the M(1) gene by an antisense oligodeoxyribonucleotide (aODN) was investigated in the mouse hot plate test. Mice received a single intracerebroventricular (i.c.v.) injection of anti-M(1) aODN (0.3, 1.0 or 2.0 nmol per injection), degenerate O...

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Détails bibliographiques
Auteurs principaux: Ghelardini, Carla, Galeotti, Nicoletta, Bartolini, Alessandro
Format: Artigo
Langue:Inglês
Publié: 2000
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572021/
https://ncbi.nlm.nih.gov/pubmed/10780968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703268
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