Nitrergic relaxation of the mouse gastric fundus is mediated by cyclic GMP-dependent and ryanodine-sensitive mechanisms

1. Ryanodine-sensitive, Ca(2+) release (‘Ca(2+) sparks') from the sarcoplasmic reticulum (SR) can activate plasmalemmal Ca(2+)-activated K(+) channels (K(Ca)) to cause membrane hyperpolarization and smooth muscle relaxation. Since cyclic guanosine monophosphate (cyclic GMP) can modulate Ca(2+)...

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Bibliografiske detaljer
Main Authors: Selemidis, Stavros, Cocks, Thomas M
Format: Artigo
Sprog:Inglês
Udgivet: 2000
Fag:
Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571963/
https://ncbi.nlm.nih.gov/pubmed/10742286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703174
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