Effect of type-selective inhibitors on cyclic nucleotide phosphodiesterase activity and insulin secretion in the clonal insulin secreting cell line BRIN-BD11

1. The cyclic nucleotide phosphodiesterases (PDEs) present in an insulin secreting cell line, BRIN–BD11, were characterized using calcium/calmodulin, IGF-1, isoenzyme-selective PDE inhibitors and RT–PCR. 2. Calmodulin activated cyclic AMP or cyclic GMP PDE activity in pellet and was 3 fold (P=0.002)...

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Autors principals: Ahmad, M, Abdel-Wahab, Y H A, Tate, R, Flatt, P R, Pyne, N J, Furman, B L
Format: Artigo
Idioma:Inglês
Publicat: 2000
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Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571945/
https://ncbi.nlm.nih.gov/pubmed/10725272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703165
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