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Preservation of mitochondrial function by diazoxide during sustained ischaemia in the rat heart

1. A possible mechanism for the action of the K(ATP) channel opener diazoxide on the improvement of energy metabolism of ischaemic/reperfused hearts was examined. 2. Isolated, perfused rat hearts were subjected to 40 min ischaemia followed by 60 min reperfusion. Diazoxide at concentrations of 3 to 3...

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Autors principals: Iwai, Takeshi, Tanonaka, Kouichi, Koshimizu, Miki, Takeo, Satoshi
Format: Artigo
Idioma:Inglês
Publicat: 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571936/
https://ncbi.nlm.nih.gov/pubmed/10725271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703148
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