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Non-prostanoid prostacyclin mimetics as neuronal stimulants in the rat: comparison of vagus nerve and NANC innervation of the colon

1. The spontaneous activity of the rat isolated colon is suppressed by prostacyclin analogues such as cicaprost (IC(50)=4.0 nM). Activation of prostanoid IP(1)-receptors located on NANC inhibitory neurones is involved. However, several non-prostanoids, which show medium to high IP(1) agonist potency...

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Autors principals: Rudd, John A, Qian, Yue-ming, Tsui, Kenneth K C, Jones, Robert L
Format: Artigo
Idioma:Inglês
Publicat: 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571884/
https://ncbi.nlm.nih.gov/pubmed/10683203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703090
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