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Participation of mitogen-activated protein kinase in thapsigargin- and TPA-induced histamine production in murine macrophage RAW 264.7 cells

1. Stimulation of the murine macrophage cell line RAW 264.7 with thapsigargin, an endomembrane Ca(2+)-ATPase inhibitor, induced histamine production in a time- and concentration-dependent manner. 2. The protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA), also enhanced histamine p...

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Main Authors: Shiraishi, Muneshige, Hirasawa, Noriyasu, Kobayashi, Yuriko, Oikawa, Shinji, Murakami, Akira, Ohuchi, Kazuo
格式: Artigo
語言:Inglês
出版: 2000
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571868/
https://ncbi.nlm.nih.gov/pubmed/10711350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703085
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