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Enhanced nociception by exogenous and endogenous substance P given into the spinal cord in mice lacking NR(2)A/ε(1), an NMDA receptor subunit
In capsaicin-pretreated mice, the nociceptive responses induced by intrathecally (i.t.) administered substance P (SP) were enhanced by N-methyl-D-aspartate (NMDA)-type receptor antagonists, dizocilpine (MK801) and D-2-amino-5-phosphonopentanoate (D-AP5) in a dose-dependent manner. Similar enhancemen...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2000
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1571840/ https://ncbi.nlm.nih.gov/pubmed/10694228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703056 |
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