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Inhibition by genistein of the hyperpolarization-activated cation current in porcine sino-atrial node cells

1. The hyperpolarization-activated cation current (I(f)) was recorded in single pacemaker cells of the porcine sino-atrial node, and the effects of genistein, an isoflavone inhibitor of tyrosine-specific protein kinases was investigated by the whole-cell patch clamp technique. 2. Genistein (20–500 μ...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Shibata, Shigehiro, Ono, Kyoichi, Iijima, Toshihiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1999
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571748/
https://ncbi.nlm.nih.gov/pubmed/10578143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702903
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