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Nociceptin (1–7) antagonizes nociceptin-induced hyperalgesia in mice

Nociceptin and its N-terminal fragment, nociceptin (1–7), were administered intrathecally (i.t.) into conscious mice. Nociceptin (3.0 fmol) produced a significant reduction in the nociceptive thermal threshold (hyperalgesia) measured as the tail-flick and paw-withdrawal responses. Nociceptin (1–7),...

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Detalhes bibliográficos
Main Authors: Sakurada, Tsukasa, Sakurada, Shinobu, Katsuyama, Sou, Sakurada, Chikai, Tan-No, Koichi, Terenius, Lars
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571734/
https://ncbi.nlm.nih.gov/pubmed/10556929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702898
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