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Cannabinoid CB(1) receptors fail to cause relaxation, but couple via G(i)/G(o) to the inhibition of adenylyl cyclase in carotid artery smooth muscle

1. The aim of the current study was to characterize which cannabinoid receptors, if any, are present on rat carotid artery smooth muscle. Additionally, the effects of cannabinoids on carotid artery tone, on cyclic AMP accumulation and on forskolin-induced relaxation were examined in the same tissue....

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Autori principali: Holland, Michael, Challiss, R A John, Standen, Nicholas B, Boyle, John P
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571683/
https://ncbi.nlm.nih.gov/pubmed/10516638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702842
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