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Block of gating currents related to K(+) channels as a mechanism of action of clofilium and d-sotalol in isolated guinea-pig ventricular heart cells
1. The possibility that the class III antiarrhythmic drugs clofilium and d-sotalol might affect delayed rectifier potassium channels at the level of their gating currents was assessed with the whole-cell patch-clamp technique in guinea-pig isolated ventricular heart cells. 2. Clofilium (up to 20 μM)...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
1999
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1571629/ https://ncbi.nlm.nih.gov/pubmed/10510439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702768 |
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