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Interleukin-1β (IL-1β) inhibition: a possible mechanism for the anti-inflammatory potency of liposomally conjugated methotrexate formulations in arthritis
1. Liposomes with conventional and long-circulation times were employed as carriers for the methotrexate derivative MTX-γ-DMPE (MTX-EPC and MTX-PEG respectively), their mechanism of action was investigated in vitro and in vivo and their therapeutic efficacy assessed using the rat collagen-induced ar...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
1999
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1571613/ https://ncbi.nlm.nih.gov/pubmed/10498857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702776 |
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