Enhancement by galactosamine of lipopolysaccharide(LPS)-induced tumour necrosis factor production and lethality: its suppression by LPS pretreatment

1. D-Galactosamine (GalN) depletes UTP primarily in the liver, resulting in decreased RNA synthesis in hepatocytes. Co-injection of GalN and lipopolysaccharide (LPS) into mice produces fulminant hepatitis with severe hepatic congestion, resulting in rapid death. Although the underlying mechanism is...

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Bibliografske podrobnosti
Main Authors: Endo, Yasuo, Shibazaki, Masahiko, Yamaguchi, Kouji, Kai, Kenzou, Sugawara, Shunji, Takada, Haruhiko, Kikuchi, Hideaki, Kumagai, Katsuo
Format: Artigo
Jezik:Inglês
Izdano: 1999
Teme:
Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571593/
https://ncbi.nlm.nih.gov/pubmed/10498828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702747
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