The development of overt diabetes in young Zucker Diabetic Fatty (ZDF) rats and the effects of chronic MCC-555 treatment

1. Young (6-week-old) pre-diabetic Zucker Diabetic Fatty (ZDF) rats displaying impaired glucose tolerance (IGT), moderate hyperglycaemia and hyperinsulinaemia were treated with the novel thiazolidinedione, MCC-555, for 28 days, during which time β-cell failure and progression to overt diabetes occur...

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Main Authors: Pickavance, L, Widdowson, P S, King, P, Ishii, S, Tanaka, H, Williams, G
Format: Artigo
Jezik:Inglês
Izdano: 1998
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Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571023/
https://ncbi.nlm.nih.gov/pubmed/9831913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702158
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