Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer

EGFR is frequently mutated and amplified in lung adenocarcinomas sensitive to EGFR inhibitors gefitinib and erlotinib. A secondary mutation, T790M, has been associated with acquired resistance but has not been shown to be sufficient to render EGFR mutant/amplified lung cancers resistant to EGFR inhi...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Engelman, Jeffrey A., Mukohara, Toru, Zejnullahu, Kreshnik, Lifshits, Eugene, Borrás, Ana M., Gale, Christopher-Michael, Naumov, George N., Yeap, Beow Y., Jarrell, Emily, Sun, Jason, Tracy, Sean, Zhao, Xiaojun, Heymach, John V., Johnson, Bruce E., Cantley, Lewis C., Jänne, Pasi A.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Clinical Investigation 2006
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC1570180/
https://ncbi.nlm.nih.gov/pubmed/16906227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28656
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