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Intricate Knots in Proteins: Function and Evolution

Our investigation of knotted structures in the Protein Data Bank reveals the most complicated knot discovered to date. We suggest that the occurrence of this knot in a human ubiquitin hydrolase might be related to the role of the enzyme in protein degradation. While knots are usually preserved among...

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Detalhes bibliográficos
Main Authors: Virnau, Peter, A. Mirny, Leonid, Kardar, Mehran
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1570178/
https://ncbi.nlm.nih.gov/pubmed/16978047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0020122
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