Preparing clinical-grade myeloid dendritic cells by electroporation-mediated transfection of in vitro amplified tumor-derived mRNA and safety testing in stage IV malignant melanoma

BACKGROUND: Dendritic cells (DCs) have been used as vaccines in clinical trials of immunotherapy of cancer and other diseases. Nonetheless, progress towards the use of DCs in the clinic has been slow due in part to the absence of standard methods for DC preparation and exposure to disease-associated...

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Detalhes bibliográficos
Main Authors: Markovic, Svetomir N, Dietz, Allan B, Greiner, Carl W, Maas, Mary L, Butler, Greg W, Padley, Douglas J, Bulur, Peggy A, Allred, Jacob B, Creagan, Edward T, Ingle, James N, Gastineau, Dennis A, Vuk-Pavlovic, Stanimir
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Methodology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1570143/
https://ncbi.nlm.nih.gov/pubmed/16911798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-4-35
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