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Genetic Exchange Between Homeologous Sequences in Mammalian Chromosomes Is Averted by Local Homology Requirements for Initiation and Resolution of Recombination

We examined the mechanism by which recombination between imperfectly matched sequences (homeologous recombination) is suppressed in mammalian chromosomes. DNA substrates were constructed, each containing a thymidine kinase (tk) gene disrupted by insertion of an XhoI linker and referred to as a “reci...

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Библиографические подробности
Главные авторы: Yang, Derek, Goldsmith, Edie B., Lin, Yunfu, Waldman, Barbara Criscuolo, Kaza, Vimala, Waldman, Alan S.
Формат: Artigo
Язык:Inglês
Опубликовано: Copyright © 2006 by the Genetics Society of America 2006
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1569803/
https://ncbi.nlm.nih.gov/pubmed/16816418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.060590
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