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Genetic Exchange Between Homeologous Sequences in Mammalian Chromosomes Is Averted by Local Homology Requirements for Initiation and Resolution of Recombination

We examined the mechanism by which recombination between imperfectly matched sequences (homeologous recombination) is suppressed in mammalian chromosomes. DNA substrates were constructed, each containing a thymidine kinase (tk) gene disrupted by insertion of an XhoI linker and referred to as a “reci...

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Main Authors: Yang, Derek, Goldsmith, Edie B., Lin, Yunfu, Waldman, Barbara Criscuolo, Kaza, Vimala, Waldman, Alan S.
Format: Artigo
Jezik:Inglês
Izdano: Copyright © 2006 by the Genetics Society of America 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1569803/
https://ncbi.nlm.nih.gov/pubmed/16816418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.060590
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