Temperature sensitive influenza A virus genome replication results from low thermal stability of polymerase-cRNA complexes

BACKGROUND: The RNA-dependent RNA polymerase of Influenza A virus is a determinant of viral pathogenicity and host range that is responsible for transcribing and replicating the negative sense segmented viral genome (vRNA). Transcription produces capped and polyadenylated mRNAs whereas genome replic...

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Bibliografiske detaljer
Main Authors: Dalton, Rosa M, Mullin, Anne E, Amorim, Maria Joao, Medcalf, Elizabeth, Tiley, Laurence S, Digard, Paul
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2006
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1569369/
https://ncbi.nlm.nih.gov/pubmed/16934156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-3-58
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