Free-radical metabolites of acetaminophen and a dimethylated derivative.

The oxidation of acetaminophen (4'-hydroxyacetanilide) to the corresponding N-acetyl-p-benzoquinone imines by plant and mammalian peroxidases is discussed. The acetaminophen free radical (N-acetyl-4-aminophenoxyl) has been reported as an intermediate. It is very reactive and forms melanin-like...

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Bibliographic Details
Main Authors: Fischer, V, West, P R, Harman, L S, Mason, R P
Format: Artigo
Language:Inglês
Published: 1985
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1568611/
https://ncbi.nlm.nih.gov/pubmed/3007084
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