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The role of intercalating residues in chromosomal high-mobility-group protein DNA binding, bending and specificity

Ubiquitous high-mobility-group (HMGB) chromosomal proteins bind DNA in a non-sequence- specific fashion to promote chromatin function and gene regulation. Minor groove DNA binding of the HMG domain induces substantial DNA bending toward the major groove, and several interfacial residues contribute b...

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Detalhes bibliográficos
Main Authors: Klass, Janet, Murphy, Frank V., Fouts, Susan, Serenil, Melissa, Changela, Anita, Siple, Jessica, Churchill, Mair E. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC156723/
https://ncbi.nlm.nih.gov/pubmed/12771212
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