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No threshold dose for estradiol-induced sex reversal of turtle embryos: how little is too much?

Risk assessments for nongenotoxic chemicals assume a threshold below which no adverse outcomes are seen. However, when an endogenous chemical, such as 17ss-estradiol (E2), occurs at a concentration sufficient to cause an effect, the threshold is already exceeded. Under these circumstances, exogenous...

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Detalhes bibliográficos
Main Authors: Sheehan, D M, Willingham, E, Gaylor, D, Bergeron, J M, Crews, D
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1566346/
https://ncbi.nlm.nih.gov/pubmed/9924012
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